Bassett Research Institute activities are centered in Cooperstown in laboratories and offices on the fourth and fifth floors (13,400 sq ft) of the building housing the Clark Education Center and the hospital lobby. A short walk from this facility, additional offices and the Research Computing Center are located on the lower level of the Cooper Inn (3,600 sq ft). All facilities are equipped with modern laboratory, computer, and communications equipment supporting the research enterprise.

The Clark Education Center, including the medical library, a multimedia computer center, and a state-of-the-art auditorium is located conveniently in the same building as the central research facilities.

The Research Institute is indebted to the Stephen C. Clark Fund for its generous continuing support of research programs. The excellent quality of these programs has also been recognized by individual donations and by the award of grants and contracts from private and public organizations. They include the National Institutes of Health, Servier, the New York State Dept. of Health, Appalachian Regional Commission, Merck, Otsuka, American Heart Association, Parke-Davis, Bristol-Meyers Squibb, Centers for Disease Control and Prevention, U.S. Dept. of Agriculture and others.